ANI
27 Sep 2022, 00:25 GMT+10
Washington [US], September 26 (ANI): New ways to study why an antibiotic causes hair cell death and permanent hearing loss in people are being developed by researchers at Indiana University School of Medicine.
In a study recently published in Developmental Cell, the researchers explained how they identified the autophagy pathway in hair cells that's linked to permanent hearing loss brought about by aminoglycosides--a class of antibiotics. The researchers also developed one of the first laboratory models that's insusceptible to aminoglycoside-induced hearing loss.
"This work identifies multiple potential therapeutic targets for preventing hearing loss caused by aminoglycosides," said Bo Zhao, PhD, assistant professor of otolaryngology--head and neck surgery.
Ototoxicity--hearing loss caused by medication--is one of the humans' main causes of hearing loss. More than 48 million people in the United States experience trouble hearing.
Aminoglycosides for nearly a century have been used to treat severe infections. Although the drug is a first-line treatment for life-threatening infections--particularly in developing countries--due to its low cost and low incidence of antibiotic resistance, it has been reported to cause hair cell death and subsequent permanent hearing loss among 20-47 per cent of patients, but the underlying mechanisms are not clear. Hair cells are responsible for sound reception in the inner ear.
Zhao, whose lab investigates the molecular mechanisms underlying hearing loss, used biochemical screening to identify proteins found in hair cells. They first discovered that aminoglycosides are bound to the protein RIPOR2, which is required for auditory perception.
"As aminoglycosides specifically trigger a rapid localization change of RIPOR2 in hair cells, we hypothesize that RIPOR2 is essential for aminoglycoside-induced hair cell death," Zhao said.
The researchers developed a model in the lab that has normal hearing but significantly decreased RIPOR2 expression. Through these experiments, Zhao said the model had neither significant hair cell death nor hearing loss after treatment of aminoglycosides.
"We then discovered RIPOR2 regulates the autophagy pathway in hair cells. Knowing this, we developed other laboratory models without the expression of several key autophagy proteins that did not exhibit hair cell death or hearing loss when treated with the antibiotic," said Jinan Li, PhD, a postdoctoral fellow in the Zhao lab and first author of the paper.
The study authors say the proteins identified in this study could potentially be used as drug targets for preventing aminoglycoside-induced hearing loss in future studies. (ANI)Get a daily dose of Orange County Sun news through our daily email, its complimentary and keeps you fully up to date with world and business news as well.
Publish news of your business, community or sports group, personnel appointments, major event and more by submitting a news release to Orange County Sun.
More InformationCHICAGO, Illinois: McDonald's is bringing back its much-loved Snack Wrap in the U.S. starting July 10. The wrap, which includes chicken,...
GOODLETTSVILLE, Tennessee: Dollar General reported record sales of US$10.44 billion for the latest quarter and raised its full-year...
THE HAGUE - The International Criminal Court (ICC) has strongly condemned the United States for imposing sanctions on four of its judges,...
LOS ANGELES, California: As obesity rates among American teenagers climb to historic levels, more families and doctors are cautiously...
SOUTH BURLINGTON, Vermont: Beta Technologies has become the first U.S. company to land an all-electric aircraft at an airport in the...
WASHINGTON, D.C. Forget bucket lists; this summer, it's all about budget lists. Amid economic uncertainty and a weaker dollar, Americans...
The Israeli Navy has intercepted a ship carrying humanitarian aid and a number of activists including Greta Thunberg, Rima Hassan,...
TOKYO, Japan: Japan's demographic challenges intensified in 2024, with the number of births falling to another all-time low—underscoring...
BEIJING, China: A little-known office inside China's Ministry of Commerce has become a powerful chokepoint in the global auto and tech...
OMAHA BEACH, France: Eighty-one years after the D-Day landings, a small group of World War II veterans has returned to the beaches...
BEIJING, China: The public security bureau in Guangzhou, a city in China, has announced a secret reward for more than 20 people it...
THE HAGUE - The International Criminal Court (ICC) has strongly condemned the United States for imposing sanctions on four of its judges,...